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Combination Therapy with Metformin plus Gliclazide in Patients with Type 2 Diabetes
Type 2 diabetes is a chronic, degenerative disease, which requires management of the symptoms via lifestyle modification and anti-diabetic pharmacotherapies. If glycaemic targets are not maintained, patients can often require the addition of a second...
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A randomized placebo-controlled study of preoperative pregabalin for postoperative analgesia in patients with spinal surgery
Study objective: To determine whether single preoperative administration of 2 different doses of pregabalin (75 and 150 mg) could decrease postoperative pain intensity and opioid consumption following posterior lumbar interbody fusion surgery. Design: Prospective, randomized, active...
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Maternal Use of Antiepileptic Agents During Pregnancy and Major Congenital Malformations in Children
CLINICAL QUESTION Is maternal use of antiepileptic drugs during pregnancy associated with major congenital malformations in children BOTTOM LINE Certain antiepileptic drugs were associated with increased rates of congenital malformations (eg, spina bifida, cardiac anomalies). Lamotrigine (2.31% in...
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EASL 2017 Clinical Practice Guidelines on the management of hepatitis B virus infectionq
Hepatitis B virus (HBV) infection remains a global public health problem with changing epidemiology due to several factors including vaccination policies and migration. This Clinical Practice Guideline presents updated recommendations for the optimal management of...
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Cardiovascular and Renal Outcomes with Empagliflozin in Heart Failure
BACKGROUND Sodium–glucose cotransporter 2 (SGLT2) inhibitors reduce the risk of hospitalization for heart failure in patients regardless of the presence or absence of diabetes. More evidence is needed regarding the effects of these drugs in patients...
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Telmisartan/hydrochlorothiazide versus valsartan/hydrochlorothiazide in obese hypertensive patients with type 2 diabetes: the SMOOTH study
Background: The Study of Micardis (telmisartan) in Overweight/Obese patients with Type 2 diabetes and Hypertension (SMOOTH) compared hydrochlorothiazide (HCTZ) plus telmisartan or valsartan fixed-dose combination therapies on early morning blood pressure (BP), using ambulatory BP...
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Empagliflozin/Linagliptin: A Review in Type 2 Diabetes
Abstract Empagliflozin/linagliptin (Glyxambi) is a once-daily sodium glucose co-transporter type 2 (SGLT2) inhibitor and dipeptidyl peptidase (DPP)-4 inhibitor fixeddose combination product that is approved in the USA as an adjunct to diet and exercise in adults...
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Effect of Alpha-Lipoic Acid on Clinical and Neurophysiologic Recovery of Carpal Tunnel Syndrome: A Double-Blind, Randomized Clinical Trial
The objective of our study was to examine the effect of alpha-lipoic acid (ALA) on clinical and neurophysiologic outcomes after surgery for idiopathic carpal tunnel syndrome (CTS). We conducted a randomized, double-blind, placebo-controlled clinical trial in...
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A Combination of High-dose Vitamin C Plus Zinc for the Common Cold
Vitamin C and zinc play important roles in nutrition, immune defence and maintenance of health. Intake of both is often inadequate, even in affluent populations. The common cold continues to place a great burden on society...
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