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Comparison of alpha lipoic with vitamin B peripheral neuropathy

. A B S T R A C T Background Vitamin B is frequently used for treating peripheral neuropathy but its efficacy is not clear. Objectives The objective of this review was to assess the effects of vitamin B for...


Does Duration of Neuropathic Pain Impact the Effectiveness of Pregabalin?

& Abstract  Background: Patients with chronic pain conditions such as neuropathic pain frequently experience delays in diagnosis and treatment. Ideally, all patients should be treated in a timely manner, but in those patients with more established disease it...


Safety of levetiracetam among infants younger than 12 months

Background: There are limited data on the use of the antiepileptic drug (AED) levetiracetam for the treatment of infants. Aim: To prospectively evaluate the safety of levetiracetam oral solution and its impact on epilepsy severity...


A randomized placebo-controlled study of preoperative pregabalin for postoperative analgesia in patients with spinal surgery

Study objective: To determine whether single preoperative administration of 2 different doses of pregabalin (75 and 150 mg) could decrease postoperative pain intensity and opioid consumption following posterior lumbar interbody fusion surgery. Design: Prospective, randomized, active...


Maternal Use of Antiepileptic Agents During Pregnancy and Major Congenital Malformations in Children

CLINICAL QUESTION Is maternal use of antiepileptic drugs during pregnancy associated with major congenital malformations in children BOTTOM LINE Certain antiepileptic drugs were associated with increased rates of congenital malformations (eg, spina bifida, cardiac anomalies). Lamotrigine (2.31% in...