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Maternal Use of Antiepileptic Agents During Pregnancy and Major Congenital Malformations in Children

CLINICAL QUESTION Is maternal use of antiepileptic drugs during pregnancy associated with major congenital malformations in children BOTTOM LINE Certain antiepileptic drugs were associated with increased rates of congenital malformations (eg, spina bifida, cardiac anomalies). Lamotrigine (2.31% in...

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